Title:
DIBENZO B,F THIEPIN DERIVATIVE
Document Type and Number:
Japanese Patent JPS5645472
Kind Code:
A
Abstract:
NEW MATERIAL:A dibenzo[b,f]thiepin derivative expressed by formula I (R1 is H or lower alkyl; R2 is H or esterified carboxy, or R1 and R2 together form phthaloyl; A is lower alkylene; X is halogen), and a salt thereof.
EXAMPLE: 8-Chloro-10-[ 2-( N-ethoxycarbonyl-N-methyl )ethoxy ]dibenzo[b,f]thiepin.
USE: A medicine having a suppressing action on the central nervous system, and an intermediate therefor.
PROCESS: A compound of formula II is reacted with a compound of formula III (Y is acid residue) to give a compound of formula Ia (R2a is esterified carboxy), which is then hydrolyzed if necessary. The hydrolysis product is decarboxylated to form the compound of formula I (R2 is H).
Inventors:
MATSUO MASAAKI
UEDA IKUO
UEDA IKUO
Application Number:
JP12229779A
Publication Date:
April 25, 1981
Filing Date:
September 21, 1979
Export Citation:
Assignee:
FUJISAWA PHARMACEUTICAL CO
International Classes:
C07D337/14; (IPC1-7): C07D337/14