Title:
DIBENZO*B*F*THIEPINE COMPOUND
Document Type and Number:
Japanese Patent JPS5444691
Kind Code:
A
Abstract:
The invention provides 7- and 8-R-dibenzo[b,f]- thiepin derivatives of formula : in which n is O or an integer from 1 to 4; Z is thio, sulfinyl, or sulfonyl; R is hydrogen, halogen, amino, C1-4 alkyl, C1-4 alkanoyl, hydroxyl, C1-4 alkoxy, mercapto, C1-4 alkylthio, C1-4 alkylsulfinyl, C1-4 alkylsulfonyl, trifluoromethyl, trifluoromethylthio, cyano, carboxy, nitro, C1-4 alkylamino or di(C1-4 alkyl)amino; A is 5-tetrazolyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy-2,5-dioxy- DELTA <3>-pyrollin-3-yl or where R2 is hydroxy, C1-4alkoxy, N,N-di(C1-4alkyl)amino-(C1-4 alkoxy), C1-4 hydroxyalkoxy, carboxy-(C1-4 alkoxy), amino, C1-4 alkylamino, di(C1-4alkyl)amino, C1-4alkylsulfonylamino, carboxy(C1-4 alkyl)amino, carbamoyl(C1-4 alkyl)amino or 2-imino-3-methylthiazolidine and the dotted line indicates either an olefinic bond or saturation at the 10, 11-position; and the pharmaceutically acceptable salts thereof. These compounds can be used in the treatment and control of allergic conditions such as allergic asthma and pharmaceutical compositions containing the compounds and methods of making the compounds are also provided.
Inventors:
JIYOSHIYUA ROKATSUCHI
KURARENSU SUTANREE RUUNII
EDOWAADO JIESURO KURAGOO JIYUN
KURARENSU SUTANREE RUUNII
EDOWAADO JIESURO KURAGOO JIYUN
Application Number:
JP9054978A
Publication Date:
April 09, 1979
Filing Date:
July 26, 1978
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/38; A61K31/41; A61P11/14; C07D337/14; C07D409/04; C07D409/06; C07D409/10; C07D417/02; C07D417/06; (IPC1-7): A61K31/38; C07D337/14; C07D409/06; C07D417/06
Domestic Patent References:
| JPS5371093A | 1978-06-24 | |||
| JPS5346989A | 1978-04-27 |