PURPOSE: To provide the subject new compound having an aldose reductase inhibitory effect and a lipoxygenase inhibitory effect and useful as a therapeutic agent for, e.g. cataract, retinopathy and neuropathy which are respectively diabetic complications or an intermediate of other medicines.
CONSTITUTION: A dibenzocyclooctane derivative of formula I [R is a hydroxyl group, a lower alkyloxy, a (substituted) benzyloxy, etc.; R1 and R4 are each hydroxyl group; R2 and R3 are each methyl or methane-sulfonyloxymethyl], e.g. (6S,7R,R-biar)-5,6,7,8-tetrahydro-2,3,6,7-tetrahydroxy-6,7-dimethyl-1,10,11,12- tetramethoxydibenzo[a,c]-cyclooctene. Among the compounds of formula I, the case in which R2 and R3 are each methanesulfonyloxymethyl can be synthesized by reacting a reducing agent with a compound of formula II to obtain a compound of formula III, subsequently reacting osmium tetraoxide therewith and conducting dihydroxylation and then methanesulfonylation.
ISHIDA YUKO
TANAKA MASAHIDE
TAKEDA SHUICHI
YOSHIDA RIE
