Title:
DIBENZOXAZEPINE DERIVATIVE
Document Type and Number:
Japanese Patent JPH03184963
Kind Code:
A
Abstract:
NEW MATERIAL:The dibenzoxazepine derivative of formula I (R is H or lower alkyl; n is 1-5) and its salt.
EXAMPLE: 4-(2-Chlorodibenz[b,f][1,4]oxazepin-11-yl)-1-piperazinepropionic acid ethyl ester.
USE: It has antidepressant, antianxiety, analgesic, antiemetic, gastroenteric motion promoting, antiarrhythmic, hypotensive or anti-allergic actions and is useful as a drug.
PREPARATION: The objective compound of formula I can be produced by reacting amoxapine of formula II with a halogen compound of formula III (X is halogen) in a solvent or in the absence of solvent at 0-100°C in the presence of a base as an acid acceptor. The base is e.g. sodium hydroxide or potassium carbonate and the reaction solvent is e.g. methanol or acetone.
Inventors:
SAWANISHI HIROYUKI
ITO YASUO
KATO HIDEO
ECCHU EIICHI
OGAWA NOBUO
MORIKAWA KOJI
ITO YASUO
KATO HIDEO
ECCHU EIICHI
OGAWA NOBUO
MORIKAWA KOJI
Application Number:
JP32156489A
Publication Date:
August 12, 1991
Filing Date:
December 13, 1989
Export Citation:
Assignee:
HOKURIKU PHARMACEUTICAL
International Classes:
C07D267/20; A61K31/55; A61P1/08; A61P1/12; A61P9/06; A61P9/12; A61P25/04; A61P25/20; A61P25/24; A61P25/26; A61P37/08; (IPC1-7): A61K31/55; C07D267/20
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