Title:
ジブロモベンジル基誘導体、その立体異性体又はその塩、ジブロモベンジル基誘導体の製造方法、呼吸器疾患を予防及び治療する薬物、去痰薬及び薬物組成物
Document Type and Number:
Japanese Patent JP7344607
Kind Code:
B2
Abstract:
Disclosed by the present invention is a dibromobenzyl derivative with a structure shown as formula I, a stereoisomer or a pharmaceutically acceptable salt thereof and a preparation method and an application of the dibromobenzyl derivative. The dibromobenzyl derivative or the stereoisomer thereof is superior in in-vivo pharmacokinetic stability and drug efficacy, and capable of being used for preparing respiratory drugs, in particular the apophlegmatic drugs.
Inventors:
Tseng Guodong
Yang Maoting
Tan Xiaojun
Yang Maoting
Tan Xiaojun
Application Number:
JP2022505248A
Publication Date:
September 14, 2023
Filing Date:
March 25, 2020
Export Citation:
Assignee:
CHENGDU SHIBEIKANG BIOMEDICAL TECHNOLOGY CO., LTD.
International Classes:
A61K31/137; C07C211/53; A61P11/00; A61P11/10; C07C209/68; C07C213/02; C07C215/44
Domestic Patent References:
| JP50012030A |
Foreign References:
| GB968254A | ||||
| CN105693764A | ||||
| US3536713 | ||||
| CN101544572A |
Other References:
CAS REGISTRY No. 1882384-54-4,No. 1877890-56-6,No. 1876716-80-1,No. 1876634-49-9,No. 1875569-33-7,No. 1874745-62-6,No. 1874601-40-7,No. 1874313-42-4,No. 1867928-90-2,No. 1867573-22-5,No. 1866379-08-9,No. 1862871-81-5,DATABASE REGISTRY,[online],2016年,[2023.03.09検索],Retrieved from :STN
LATLI, B. et al.,“Synthesis of labeled ambroxol and its major metabolites”,Journal of Labelled Compounds and Radiopharmaceuticals,2009年,Vol. 53, No. 1,pp. 15-23,DOI: 10.1002/jlcr.1694
LATLI, B. et al.,“Synthesis of labeled ambroxol and its major metabolites”,Journal of Labelled Compounds and Radiopharmaceuticals,2009年,Vol. 53, No. 1,pp. 15-23,DOI: 10.1002/jlcr.1694
Attorney, Agent or Firm:
Patent Attorney Corporation ATEN