Title:
癌の診断及び治療に用いられる示差的に発現する腫瘍特異的ポリペプチド
Document Type and Number:
Japanese Patent JP2007521015
Kind Code:
A
Abstract:
The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin-like protein (SYPL), stomatin-like 2 (STOML2), Ras-related GTP-binding protein RAGA), nucleotide-sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.
Inventors:
Bushman, Thomas
Fortiadis, Nicoletta-Kiriaki
Hooks, Miriam
Heim, Siten
Irina, Tatiana
Lamere, Citéfani
Moyer, yarn
Rotman-Cothic, Kiasten
Cyberto, Volker
Perez, Sylvia, Totora
Fortiadis, Nicoletta-Kiriaki
Hooks, Miriam
Heim, Siten
Irina, Tatiana
Lamere, Citéfani
Moyer, yarn
Rotman-Cothic, Kiasten
Cyberto, Volker
Perez, Sylvia, Totora
Application Number:
JP2006526617A
Publication Date:
August 02, 2007
Filing Date:
September 20, 2004
Export Citation:
Assignee:
GENMAB A/S
International Classes:
C12Q1/68; A61K31/7088; A61K35/76; A61K39/395; A61K45/00; A61K47/28; A61K47/44; A61K48/00; A61P1/00; A61P17/00; A61P35/00; C07K16/28; C12P21/08; G01N33/15; G01N33/50; G01N33/566; G01N33/574; G01N33/68
Other References:
JPN6010035818, Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ ｂｉｏｐｈｙｓｉｃａｌ ｒｅｓｅａｒｃｈ ｃｏｍｍｕｎｉｃａｔｉｏｎｓ． ２００１， Ｖｏｌ．２８５， Ｎｏ．５， ｐ．１２４４−１２４９
JPN6010035822, Ｂｉｏｃｈｅｍｉｃａｌ ｐｈａｒｍａｃｏｌｏｇｙ． ２００１， Ｖｏｌ．６２， Ｎｏ．１０， ｐ．１３１１−１３３６
JPN6010035822, Ｂｉｏｃｈｅｍｉｃａｌ ｐｈａｒｍａｃｏｌｏｇｙ． ２００１， Ｖｏｌ．６２， Ｎｏ．１０， ｐ．１３１１−１３３６
Attorney, Agent or Firm:
Mizuno Yuuki
Junji Endo
Junji Endo