Title:
GLP-1またはExendin-4による、非インスリン産生細胞のインスリン産生細胞への分化、およびその使用
Document Type and Number:
Japanese Patent JP4624558
Kind Code:
B2
Abstract:
The present invention relates to a population of insulin producing cells made by a process comprising contacting non-insulin producing cells with a growth factor selected from the group consisting of GLP-1 or Exendin-4, growth factors having amino acid sequences substantially homologous to GLP-1 or Exendin-4, and fragments thereof. The present invention also relates to methods of differentiating non-insulin producing cells into insulin producing cells and of enriching a population of cells for insulin-producing cells. The present invention also relates to methods of treating diabetes.
Inventors:
Egan, Josephine
Perfetti, Ricardo
Anthony, Passanity
Greig, Nigel
Holloway, Harold
Perfetti, Ricardo
Anthony, Passanity
Greig, Nigel
Holloway, Harold
Application Number:
JP2000565103A
Publication Date:
February 02, 2011
Filing Date:
August 10, 1999
Export Citation:
Assignee:
The Government of the United States of America, As Represented by the Secretary, Department of Health and Human Services
International Classes:
C12N5/071; C12N15/09; A61K35/39; A61K38/04; A61K38/22; A61K38/26; A61P3/10; C07K14/575; C12Q1/68; A61K35/12; C12R1/91
Domestic Patent References:
| JP10500114A | ||||
| JP7505786A |
Other References:
J.Biol.Chem.,1996年,Vol.137, No.9,p.3969-3976
Mol Med,1996年,Vol.33, No.7,p.806-811
J Clin Invest,1996年,Vol.97,p.1647-1654
Mol Med,1996年,Vol.33, No.7,p.806-811
J Clin Invest,1996年,Vol.97,p.1647-1654
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Hiroshi Yamazaki