Title:
HCVセリンプロテアーゼ阻害剤としての二フッ素化トリペプチド
Document Type and Number:
Japanese Patent JP2011510927
Kind Code:
A
Abstract:
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Inventors:
Guy, Yonghua
Oa, Yatto Seung
One, Jia
Oa, Yatto Seung
One, Jia
Application Number:
JP2010544412A
Publication Date:
April 07, 2011
Filing Date:
January 22, 2009
Export Citation:
Assignee:
Enanta Pharmaceuticals, Inc.
International Classes:
C07K5/083; A61K31/13; A61K31/427; A61K38/00; A61K38/21; A61K38/55; A61K45/00; A61P31/12; A61P31/14; A61P43/00; C07K5/087; C07K5/097; C12N9/99
Attorney, Agent or Firm:
Kawaguchi International Patent Office