Title:
DIFLUOROPROSTAGLANDIN DERIVATIVE AND ITS USE
Document Type and Number:
Japanese Patent JP3480549
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject new compound having excellent intraocular pressure-decreasing activities, hardly providing eye irritation and influence to ocular tissue such as cornea, iris and conjunctiva, and also excellent in persistance of the activities, and suitably usable as a medicine for an eye disease.
SOLUTION: This compound is a fluorine-containing prostaglandin derivative of the formula [A is ethylene, vinylene, ethynylene or the like; R1 is a 3-8C alkyl, a 3-8C alkenyl or the like; R2 and R3 are each independently H, acyl or the like; X is CH2, O or the like; Z is OR4 (R4 is H, an alkyl, an alkynyl, an alkenyl or the like), NHCOR5 (R5 is the same as R4) or the like] or a salt thereof, for example, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20- tetranorprostaglandin F2α is cited. For example, a compound of the formula can be synthesized by using a Corey lactone as a starting material and further using a method similar to general Prostaglandin F2α.
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Inventors:
Eiichi Shirasawa
Masaaki Kageyama
Tadashi Nakajima
Takashi Nakano
Nobuaki Mori
Hidefumi Sasakura
Yasushi Matsumura
Yoshitomi Morisawa
Masaaki Kageyama
Tadashi Nakajima
Takashi Nakano
Nobuaki Mori
Hidefumi Sasakura
Yasushi Matsumura
Yoshitomi Morisawa
Application Number:
JP34334397A
Publication Date:
December 22, 2003
Filing Date:
December 12, 1997
Export Citation:
Assignee:
Santen Pharmaceutical Co., Ltd.
Asahi Glass Co., Ltd.
Asahi Glass Co., Ltd.
International Classes:
A61K31/5575; A61K31/557; A61P27/02; A61P27/06; C07C405/00; (IPC1-7): C07C405/00; A61K31/557; A61P27/06
Domestic Patent References:
| JP770054A |
Attorney, Agent or Firm:
Mamoru Tsunoda
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