Title:
DIFUNCTIONAL COMPOUND
Document Type and Number:
Japanese Patent JPS6110537
Kind Code:
A
Abstract:
NEW MATERIAL:A compound of therformula [C(=O)-Z is reactive derivative of carboxyl group].
EXAMPLE: N-Succinimidyl-p-(2-nitrovinyl)-benzoate.
USE: Difunctional crosslinking agent: it is used to bind a compound bearing an amino group with another compound bearing a thiol group.
PREPARATION: The reaction of p-(2-nitrovinyl)benzoic acid with 2,4-dinitrophenol derivative or N-hydroxysuccinimide derivative is carried out in a solvent such as THF or DMF in the presence of a dehydrating agent such as dicyclohexylcarbodiimide to give the compound of the formula. The compound of the formula is used to combine, e.g., peptides or steroids.
Inventors:
FUJII NOBUTAKA
AKAMICHI KENICHI
FUTAKI SHIROU
AKAMICHI KENICHI
FUTAKI SHIROU
Application Number:
JP13140784A
Publication Date:
January 18, 1986
Filing Date:
June 25, 1984
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO
International Classes:
C07D207/46; C07C67/00; C07C201/00; C07C205/54; C07C313/00; C07C323/60; C07K16/00; C07K17/06; C07K19/00; C12N11/06; G01N33/531; (IPC1-7): C07C79/22; C07C149/273; C07D207/46; C07K17/06; C12N11/06; G01N33/531
Attorney, Agent or Firm:
Moroishi Mitsuhiro
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