To provide a method for producing a dihydroquinoxalin-2-on derivative, which does not require many steps and is environmentally friendly, to provide a new dihydroquinoxalin-2-on derivative, and to provide a therapeutic agent for cancer.
The method for producing the dihydroquinoxalin-2-on derivative comprises a one-pot cyclization reaction between a (heterocyclic) aromatic compound having a halogen and an amino group as neighboring substituents, e.g. a 2-haloaniline derivative, and an α-amino acid derivative. Preferably, a copper catalyst, a base and an aprotic polar solvent are used. The derivative may be an optically active substance. The therapeutic agent for cancer comprises the dihydroquinoxalin-2-on derivative as an active ingredient and is particularly effective for treating human uterine cervical cancer.
KIRIHATA MITSUMUNE
Kyousei Tamura
New exemption victory