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Title:
γ- DIKETONE AS Wnt/β-CATENIN SIGNAL TRANSDUCTION PATHWAY ACTIVATOR
Document Type and Number:
Japanese Patent JP2019031496
Kind Code:
A
Abstract:
To provide γ-diketone or an analog thereof for activating Wnt/β-catenin signal transduction and treating or preventing diseases related to the signal transduction.SOLUTION: There is provided a compound of the formula I or a pharmaceutically acceptable salt thereof. In the formula, A ring is 7- to 12-membered heteroaryl and a carbon atom on the ring binds to carbonyl carbon; B ring is selected from a group consisting of phenyl and 5- to 6-membered heteroaryl, and a carbon atom on the ring binds to carbonyl carbon; Ris a substituent binding to the A ring and independently for each occurrence, H, unsubstituted Cto Calkyl or the like; Ris a substituent binding to the B ring and independently for each occurrence, H, unsubstituted Cto Calkyl or the like.SELECTED DRAWING: None

Inventors:
ケイシー スニル クマー
ワラス デイビッド マーク
フード ジョン
バローガ シャーリーン エフ.
Application Number:
JP2018166538A
Publication Date:
February 28, 2019
Filing Date:
September 06, 2018
Export Citation:
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Assignee:
サミュメッド リミテッド ライアビリティ カンパニー
International Classes:
C07D319/18; A61K9/06; A61K9/107; A61K31/12; A61K31/343; A61K31/353; A61K31/357; A61K31/36; A61K31/381; A61K31/385; A61K31/39; A61K31/404; A61K31/416; A61K31/4184; A61K31/423; A61K31/4402; A61K31/4409; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/50; A61K31/501; A61K31/505; A61K31/506; A61L29/00; A61P1/02; A61P1/04; A61P7/06; A61P9/10; A61P17/00; A61P17/02; A61P17/14; A61P19/00; A61P19/02; A61P19/10; A61P25/00; A61P25/08; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P27/16; A61P43/00; C07C49/84; C07D209/08; C07D209/12; C07D213/50; C07D231/56; C07D235/08; C07D237/08; C07D239/26; C07D263/56; C07D307/79; C07D311/58; C07D317/54; C07D327/06; C07D333/22; C07D333/54; C07D339/08; C07D401/06; C07D405/06; C07D407/06; C07D409/06; C07D411/06; C07D413/06
Attorney, Agent or Firm:
清水 初志
春名 雅夫
山口 裕孝
刑部 俊
井上 隆一
佐藤 利光
新見 浩一
小林 智彦
小寺 秀紀
大関 雅人
五十嵐 義弘
川本 和弥