Title:
DIOXANE ADDITION COMPOUND
Document Type and Number:
Japanese Patent JP2599105
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound, useful as a synthetic intermediate for cephem compounds which are excellent antimicrobial agents and capable of industrially providing the cephem compounds in high yield and purity.
CONSTITUTION: This dioxane addition compound of 7β-[(Z)-2-(2-aminothiazol-4- yl)-2-methoxyiminoacetamido]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-Δ3-cephem-4- carboxylic acid (syn-isomer) is expressed by formula I. The compound is obtained by acylating a compound (syn-isomer) expressed by formula 11 (X is a halogen) or its salt with a compound expressed by formula III or its salt in a solvent such as THF usually at -35 to +25°C for several min to several hr, providing a compound expressed by formula IV (syn-isomer) or its salt, then dehydrating the resultant compound and subsequently treating the dehydrated compound with dioxane under acidic conditions of preferably pH2.5-3.
Inventors:
Hiroyuki Imaizumi
Taiki Inaba
Junichi Yoshida
Yoshino
Takanobu Takeno
Shuntaro Takano
Saigawa Isamu
Taiki Inaba
Junichi Yoshida
Yoshino
Takanobu Takeno
Shuntaro Takano
Saigawa Isamu
Application Number:
JP30282094A
Publication Date:
April 09, 1997
Filing Date:
November 11, 1994
Export Citation:
Assignee:
Toyama Chemical Co., Ltd.
International Classes:
C07D319/12; A61K31/545; A61K31/546; A61P31/04; C07D501/46; (IPC1-7): C07D501/46; C07D319/12
Domestic Patent References:
| JP5799592A | ||||
| JP5661388A | ||||
| JP5283574A |
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