Title:
Dipeptide joint medicine agent
Document Type and Number:
Japanese Patent JP6101202
Kind Code:
B2
Abstract:
A non-enzymatically self cleaving dipeptide element is provided that can be linked to known medicinal agents via an amide bond. The dipeptide will spontaneously be cleaved from the medicinal agent under physiological conditions through a reaction driven by chemical instability. Accordingly, the dipeptide element provides a means of linking various compounds to known medicinal agents wherein the compounds are subsequently released from the medicinal agent after a predetermined time of exposure to physiological conditions. For example, the dipeptide can be linked to an active site of a drug to form a prodrug and/or the dipeptide may comprise a depot polymer to sequester an injectable composition comprising the complex at the point of administration.
Inventors:
Dimarchi, Richard, Dee.
Application Number:
JP2013516595A
Publication Date:
March 22, 2017
Filing Date:
June 09, 2011
Export Citation:
Assignee:
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
International Classes:
A61K38/00; A61K38/095; A61K47/10; A61P43/00
Other References:
Int J Pept Res Ther,2008年,Vol.14, Issue 4,p.255-62
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation
Previous Patent: Polyurethane content ink-jet ink
Next Patent: AUTOMATICALLY FINISHING DEVICE FOR WELDING SECTION OF RAIL
Next Patent: AUTOMATICALLY FINISHING DEVICE FOR WELDING SECTION OF RAIL