To provide a disaster prevention residence which has a strong structure with such high pressure resistance and water tightness as to endure impacts of tsunami or the like, is not expensive, and can be easily evacuated from.

A disaster prevention residence 1 includes: functions as a living space for living a daily life and as a disaster prevention shelter for protecting human life in a case of a disaster; a structural skeleton 11 having a reinforced concrete foundation heavy structure integrally configured with an underground lower story 3 and a ground upper story 5; an outer wall part 15 having an opening 13 formed on an outer peripheral surface of the structural skeleton 11; a floor structure 17 having the opening 13 partitioning the lower story 3 and the upper story 5; and a door body 19 or a window part 21 having a pressure resistant watertight construction blocking the opening 13 in an openable and closable manner. A cushioning wave form shape 29 moderating impacts of tsunami is applied to a part of the upper story 5 or a sea side surface 25 of the entire outer wall part 15, and one side or both sides of inland side surfaces 27.