Title:
BONE/JOINT DISEASE-SUSCEPTIBLE GENE AND USE THEREOF
Document Type and Number:
Japanese Patent JP2006042735
Kind Code:
A
Abstract:
To provide a method for diagnosing genetic susceptibility to bone/joint diseases and to provide a prophylactic/therapeutic agent, etc., for the bone/joint diseases.
The method for diagnosing the genetic susceptibility to the bone/joint diseases (e.g. osteoarthritis) comprises detecting polymorphism present in GDF5 (growth and differentiation factor 5)gene and/or its peripheral region. A means for prophylaxis and therapy of the bone/joint diseases comprises regulating (promoting or inhibiting) the expression or activity of the GDF5.
Inventors:
IKEGAWA SHIRO
MABUCHI AKIHIKO
MABUCHI AKIHIKO
Application Number:
JP2004231749A
Publication Date:
February 16, 2006
Filing Date:
August 06, 2004
Export Citation:
Assignee:
RIKAGAKU KENKYUSHO
MABUCHI AKIHIKO
MABUCHI AKIHIKO
International Classes:
C12N15/09; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P35/00; C12Q1/68; G01N33/15; G01N33/50; G01N33/53
Other References:
JPN6010024270, Ｎａｔ． Ｇｅｎｅｔ．， ｖｏｌ． １２， ｐａｇｅｓ ３１５−３１７ （１９９６）
JPN6010024256, ＳＲＬ宝函，第２７巻，第３９−４３頁（２００３年）
JPN6010024258, 別冊整形外科，第４２号，第１７−２０頁（２００２年）
JPN6010024260, 腎と骨代謝，第１７巻，第１３−１９頁（２００４年１月）
JPN6010024262, Ｈｕｍ． Ｍｏｌ． Ｇｅｎｅｔ．， ｖｏｌ． １６， ｐａｇｅｓ ２３６６−２３７５ （２００７）
JPN6010024273, Ｎａｔ． Ｇｅｎｅｔ．， ｖｏｌ． ３９， ｐａｇｅｓ ５２９−５３３ （２００７）
JPN6010024264, 骨・関節・靭帯，第２０巻，第８６１−８６６頁（２００７年）
JPN6010024266, Ｊ． Ｃｅｌｌ Ｂｉｏｌ．， ｖｏｌ． １４４， ｐａｇｅｓ １６１−１７３ （１９９９）
JPN6010024269, Ｊ． Ｂｏｎｅ Ｍｉｎｅｒ． Ｒｅｓ．， ｖｏｌ． １３， ｐａｇｅｓ ３８３−３９２ （１９９８）
JPN6010024256, ＳＲＬ宝函，第２７巻，第３９−４３頁（２００３年）
JPN6010024258, 別冊整形外科，第４２号，第１７−２０頁（２００２年）
JPN6010024260, 腎と骨代謝，第１７巻，第１３−１９頁（２００４年１月）
JPN6010024262, Ｈｕｍ． Ｍｏｌ． Ｇｅｎｅｔ．， ｖｏｌ． １６， ｐａｇｅｓ ２３６６−２３７５ （２００７）
JPN6010024273, Ｎａｔ． Ｇｅｎｅｔ．， ｖｏｌ． ３９， ｐａｇｅｓ ５２９−５３３ （２００７）
JPN6010024264, 骨・関節・靭帯，第２０巻，第８６１−８６６頁（２００７年）
JPN6010024266, Ｊ． Ｃｅｌｌ Ｂｉｏｌ．， ｖｏｌ． １４４， ｐａｇｅｓ １６１−１７３ （１９９９）
JPN6010024269, Ｊ． Ｂｏｎｅ Ｍｉｎｅｒ． Ｒｅｓ．， ｖｏｌ． １３， ｐａｇｅｓ ３８３−３９２ （１９９８）
Attorney, Agent or Firm:
Takashima Ichi