Title:
移植片対宿主病の処置または予防の方法
Document Type and Number:
Japanese Patent JP2019512493
Kind Code:
A
Abstract:
ヒト患者においてＧｖＨＤを処置または予防する方法であって、ＧｖＨＤを患っているまたはＧｖＨＤを患うリスクのある患者へ、ヒトα４β７インテグリンに対する結合特異性を有するヒト化抗体を投与することを含む方法。
Inventors:
Saxophone, Jessica A.
Ford, John Yee.
Ford, John Yee.
Application Number:
JP2018548192A
Publication Date:
May 16, 2019
Filing Date:
March 13, 2017
Export Citation:
Assignee:
MILLENNIUM PHARMACEUTICALS, INC.
International Classes:
A61K39/395; A61K31/519; A61K31/706; A61K45/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07K16/28; C12N5/0789
Other References:
"Targeting Integrin a4b7-Expressing T-Cells in Steroid Refractory Intestinal GvHD", BLOOD, vol. 126, no. 23, JPN6021013982, 2015, pages 3137, ISSN: 0004487973
"EXPRESSION OF α4β7 INTEGRIN ON MEMORY CD8+ T-CELLS IS INCREASED IN PATIENTS AT PRESENTATION OF ACU", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, vol. 18, no. 2, JPN6021013984, 2011, pages 221 - 49, ISSN: 0004487974
"EXPRESSION OF α4β7 INTEGRIN ON MEMORY CD8+ T-CELLS IS INCREASED IN PATIENTS AT PRESENTATION OF ACU", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, vol. 18, no. 2, JPN6021013984, 2011, pages 221 - 49, ISSN: 0004487974
Attorney, Agent or Firm:
Yoshinori Hosoda