Title:
Disposal of the modulator of GPR119 receptor, and the obstacle relevant to it
Document Type and Number:
Japanese Patent JP5941916
Kind Code:
B2
Abstract:
The present invention relates to the GPR119 receptor agonists: 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)- N , N- dimethylbenzamide; 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)- N -methylbenzamide; and 3-fluoro-4-(5-fluoro-6-(4-(3-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pyrimidin-4-ylamino)benzamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as a single pharmaceutical agent or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of, for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing secretion of an incretin; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto.
Inventors:
Jones, Robert M.
Lehman, Yog
Chen, Wei Chao
Edwards, Jeffrey
Marquez, Glen
Morgan, Michael E.
Saddek, Abu Jay. M.
Kim, Seung Hee
Lehman, Yog
Chen, Wei Chao
Edwards, Jeffrey
Marquez, Glen
Morgan, Michael E.
Saddek, Abu Jay. M.
Kim, Seung Hee
Application Number:
JP2013529426A
Publication Date:
June 29, 2016
Filing Date:
September 21, 2011
Export Citation:
Assignee:
Arena Pharmaceuticals, Incorporated
International Classes:
C07D413/14; A61K31/506; A61K45/00; A61P1/02; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P19/02; A61P19/08; A61P19/10; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/12; A61P29/00
Domestic Patent References:
| JP2008501698A | ||||
| JP2006516572A | ||||
| JP2007528856A | ||||
| JP2009533447A |
Foreign References:
| WO2010075273A1 | ||||
| WO2010084944A1 | ||||
| WO2010008739A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
Previous Patent: How to Pot processing by carrying out the surface of aqueous acids, an etching solution, a single cr...
Next Patent: JPS5941917
Next Patent: JPS5941917