PURPOSE: To obtain the subject new compound, having excellent suppressing actions on gastric acid secretion and antimicrobial actions on Helicobacter pylori and useful as a preventing and therapeutic agent for ulcerative diseases and a preventing agent for relapse thereof.
CONSTITUTION: A disubstituted thiophene compound of formula I (R1 is a 3- to an 8-membered cyclic amino, a mono- or a di-1-4C alkylamino; R2 is a 6-10C aryl, etc.; A is a 3-5C alkylene which may have a double bond; B is a single bond or a 1-3C alkylene; D is a single bond or a 1-3C alkylene; X is a single bond, O, S, sulfinyl or sulfonyl, with the proviso that X is the single bond when B is the single bond) or its pharmacologically permissible salt, e.g. N-[4-(5- piperidinomethyl-3-thienyloxy)-2- -butenyl]-(phenoxy)acetamide. The compound of formula I is obtained by using, e.g. an amine derivative of formula II and a carboxylic acid of formula III or its reactive derivative according to a conventional method, in a method for synthesizing a peptide, e.g. by an active ester method, etc.
KOYAMA KAZUO
KURATA HITOSHI
FUKUMI HIROSHI
TABATA KEIICHI
YASUDA HIROSHI
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