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Title:
DISUBSTITUTED THIOPHENE COMPOUND
Document Type and Number:
Japanese Patent JPH08127581
Kind Code:
A
Abstract:

PURPOSE: To obtain the subject new compound, having excellent suppressing actions on gastric acid secretion and antimicrobial actions on Helicobacter pylori and useful as a preventing and therapeutic agent for ulcerative diseases and a preventing agent for relapse thereof.

CONSTITUTION: A disubstituted thiophene compound of formula I (R1 is a 3- to an 8-membered cyclic amino, a mono- or a di-1-4C alkylamino; R2 is a 6-10C aryl, etc.; A is a 3-5C alkylene which may have a double bond; B is a single bond or a 1-3C alkylene; D is a single bond or a 1-3C alkylene; X is a single bond, O, S, sulfinyl or sulfonyl, with the proviso that X is the single bond when B is the single bond) or its pharmacologically permissible salt, e.g. N-[4-(5- piperidinomethyl-3-thienyloxy)-2- -butenyl]-(phenoxy)acetamide. The compound of formula I is obtained by using, e.g. an amine derivative of formula II and a carboxylic acid of formula III or its reactive derivative according to a conventional method, in a method for synthesizing a peptide, e.g. by an active ester method, etc.


Inventors:
KOJIMA KOICHI
KOYAMA KAZUO
KURATA HITOSHI
FUKUMI HIROSHI
TABATA KEIICHI
YASUDA HIROSHI
Application Number:
JP1995000006595
Publication Date:
May 21, 1996
Filing Date:
January 19, 1995
Export Citation:
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Assignee:
SANKYO CO
International Classes:
C07D333/32; A61K31/38; A61K31/381; A61K31/40; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/4433; A61K31/445; A61K31/50; A61K31/505; A61P1/00; A61P1/04; A61P31/04; C07D409/12; C07D413/12; C07D417/12; (IPC1-7): C07D333/32; A61K31/38; A61K31/40; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/44; A61K31/445; A61K31/50; A61K31/505; C07D409/12; C07D413/12; C07D417/12
Attorney, Agent or Firm:
大野 彰夫 (外2名)