Title:
DITERPENE LACTONE COMPOUND AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH03178977
Kind Code:
A
Abstract:
NEW MATERIAL: A compound of formula I (R1 is a halogen, OH, methoxy or propylthio; R2 is H or acetyl).
USE: Antiinflammatory agents or immunosuppressants.
PROCESS: A triptolide of formula II is reacted with a compound of formula R1-H and then with acetic anhydride to give a diterpene lactone of formula I. As the example of R1-H are mentioned HCl, HBr, HI, methanol, propanethiol, etc. The reaction is effected usually at a temp. of 2 to 3°C in a refrigerator or at a temp. from room temperature to 70°C. The reaction solvent includes, for example, ethyl ether, methanol, acetone, etc.
Inventors:
RU SHI YU
ZENGU JIA RAN
MA PENGU CHIENGU
ZANGU CHIYONGU PU
CHIEN YUN
YU DE KUAN
U RUO SHIYU
RIANGU SHIAO TEIAN
ZANGU ZENGU SHINGU
ZENGU JIA RAN
MA PENGU CHIENGU
ZANGU CHIYONGU PU
CHIEN YUN
YU DE KUAN
U RUO SHIYU
RIANGU SHIAO TEIAN
ZANGU ZENGU SHINGU
Application Number:
JP21360890A
Publication Date:
August 02, 1991
Filing Date:
August 10, 1990
Export Citation:
Assignee:
CHUGOKU IGAKU KAGAKUIN HIFUBIY
CHUGOKU IGAKU KAGAKUIN YAOBUTS
CHUGOKU IGAKU KAGAKUIN YAOBUTS
International Classes:
C07D493/14; A61K31/34; A61K31/365; A61K31/56; A61P29/00; A61P37/06; C07B39/00; C07B41/02; C07B45/06; C07D493/22; C07J71/00; (IPC1-7): C07D493/14; C07D493/22
Attorney, Agent or Firm:
Akira Asamura (3 outside)