PURPOSE: To provide a diuretic for accelerating the excretion of bile to improve the retention of the bile by containing ursodeoxycholic acid-3-glucuronide as an active ingredient.
CONSTITUTION: A diuretic contains ursodeoxycholic acid-3-glucuronide of the formula. The compound can be prepared by the application of a known method for the glucuronic acid complex of a bile acid. The dose of the compound is 10-4000mg/adult/day, preferably 100-2000mg/adult/day, on oral administration and 5-1000mg/adult/day, preferably 50-600mg. on intravenous injection, and dose being administrated after divided into 1-6 parts, preferably 1-3 parts. The diuretic includes tablets, capsules, etc., containing the compound of the formula and a physiologically harmless solid or liquid preparation carrier. The agent can be expected to be applied to primary biliary liver cirrhosis similar to ursodeoxycholic acid.
YAMANAKA MASAMI
SANO MASAYO
TOKYO TANABE CO
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