Diversification of human milk oligosaccharide (HMO) or its precursor

Title:

Diversification of human milk oligosaccharide (HMO) or its precursor

Document Type and Number:

Japanese Patent JP6106160

Kind Code:

B2

Abstract:

A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises the steps ofa) providing at least one compound or a mixture of the compounds selected from the group consisting of:- optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof:whereinR is a group removable by hydrogenolysis,R₁ independently of each other is fucosyl or HR₄ independently of each other is sialyl or H,provided that the compound of general formula 2 is not R-glycoside of lactose, if provided alone;- optionally sialylated and/or fucosylated lactose derivatives of general formula 4 and salts thereof:whereinR₁ independently of each other is fucosyl or HR₄ independently of each other is sialyl or H,provided that the compound of general formula 4 is not lactose, if provided alone;- lacto-N-tetraose (LNT):- lacto-N-tetraose (LNT) derivatives of the following formula:wherein R is a group removable by hydrogenolysis;- lacto-N-neotetraose (LNnT):- lacto-N-neotetraose (LNnT) derivatives of the following formula:wherein R is a group removable by hydrogenolysis;b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); andc) incubating the mixture obtained according to step b).

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Inventors:

Decane, Jura
Champion, Elise
Schroven, Andreas
Marathus, Hederos

Application Number:

JP2014510920A

Publication Date:

March 29, 2017

Filing Date:

May 14, 2012

Export Citation:

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Assignee:

GLYCOM A/S

International Classes:

C12P19/18; A23C9/152; A23L33/10; A61K31/702; A61P3/02; A61P37/02

Domestic Patent References:

JP2007525487A
JP2005500058A
JP2001514865A

Foreign References:

WO1993018787A1
WO1994025615A1

Attorney, Agent or Firm:

Kishimoto Tatsuto
Akihiko Yamashita
Noriyuki Yamamoto

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