Title:
(±)−フェニル[4−[4−[[[4’−(トリフルオロメチル)−2−ビフェニリル]カルボニル]アミノ]フェニル]−1−ピペリジニル]酢酸メチルの分割
Document Type and Number:
Japanese Patent JP5596134
Kind Code:
B2
Abstract:
The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
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Inventors:
コプマン, アレクス Hermann
Hort, Jerome Albert Joseph
Oui Remsen, the Albert Louis announcer
Koock, ウーター Louis Jaye
Van Doe Ann, ヨアネ Petrus
Hort, Jerome Albert Joseph
Oui Remsen, the Albert Louis announcer
Koock, ウーター Louis Jaye
Van Doe Ann, ヨアネ Petrus
Application Number:
JP2012512376A
Publication Date:
September 24, 2014
Filing Date:
May 27, 2010
Export Citation:
Assignee:
Jansen pharmacy you surf smelt ナーム rose フエンノートシヤツプ JANSSENPHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D211/34; A61K31/451; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07B57/00
Attorney, Agent or Firm:
Patent business corporation Odajima patent firm