To provide a chimeric molecule comprising an amino acid sequence of KGF (keratin cell growth factor) and an amino acid sequence of at least one other member of FGF (fibroblast growth factor) peptide family.
A chimeric protein comprises following (1) and (2): (1) an amino acid sequence having selective mitogenic activity on epithelial cells and consisting of (a) an amino acid sequence represented by amino acid No. 32 to 64 and No. 157 to 161 in the following amino acid sequence or (b) an amino acid sequence represented by amino acid No. 32 to 64 in the following amino acid sequence and which is different in deletion of one or more amino acids contiguous from N-terminus; MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT; and (2) at least one slice of the member of fibroblast growth factor family.
FINCH PAUL W
AARONSON STUART A
FINCH PAUL W
AARONSON STUART A
Sadao Muramatsu
Ryo Hashimoto