Title:
DNA SEQUENCE OF EBV GENOME
Document Type and Number:
Japanese Patent JP3164497
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new DNA sequence encoding an Epstein-Barr-Virus(EBV)- related antigen protein having a specific amino acid sequence and useful for producing the EBV-related antigen protein used for preventing and treating EBV-related diseases, or the like.
SOLUTION: This new DNA sequence of an EBV genome corresponds to at least a part of an EBV-related antigen protein having an amino acid sequence containing amino acid sequences expressed by formulas I and II. The new DNA sequence is useful for producing the EBV-related antigen protein for diagnosing, preventing and treating EBV-related diseases such as African Burkitt's lymphoma(BL), nasopharyngeal carcinoma(NPC) and infectious mononucleosis. The DNA sequence is obtained by extracting a genome DNA from EBV collected from the serum of a patient of the infectious mononucleosis or the nasopharyngeal carcinoma(NPC), producing an EBV library from the genome DNA by a conventional method and subsequently screening the EBV library with a probe comprising a part of a gene encoding the EBV-related antigen protein.
Inventors:
Hans Yacht Wolf
Application Number:
JP26609995A
Publication Date:
May 08, 2001
Filing Date:
September 07, 1995
Export Citation:
Assignee:
Hans Yacht Wolf
International Classes:
G01N33/569; A61K39/245; A61P31/12; C07H21/04; C07K14/05; C12N1/21; C12N15/09; C12P21/02; C12Q1/70; G01N33/577; A61K38/00; A61K39/00; C12R1/19; (IPC1-7): C12N15/09; C07H21/04; C12N1/21; C12P21/02; G01N33/569; C12R1:93
Other References:
Ｊｏｕｒｎａｌ ｏｆ ｖｉｒｏｌｏｇｙ，Ｖｏｌ．４３，ｎｏ．２，ｐ．７３０−７３６
Ｎａｔｕｖｅ，ｖｏｌ．３１０，（１９ Ｊｕｌｙ １９８４）ｐ．２０７−２１１
Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ．ｖｏｌ．７７，ｎｏ．９ ｐ．５３０７−５３１１
Ｎａｔｕｖｅ，ｖｏｌ．３１０，（１９ Ｊｕｌｙ １９８４）ｐ．２０７−２１１
Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ．ｖｏｌ．７７，ｎｏ．９ ｐ．５３０７−５３１１
Attorney, Agent or Firm:
Minoru Nakamura (4 outside)