To provide a synthetic compound that has sufficient water solubility, can efficiently and economically be produced, and has the same biological activity as those of dolastatine 15.
A cell growth inhibitor that is a peptide represented by formula (I): A-B-D-E-F-(G)r-(K)s-L, and its salt are provided. Therein, A, B, D, E, F, G and K are each an -amino acid residue; (s) and (r) are each independently 0 or 1; L is a monovalent radical such as an amino group, an N-substituted amino group, a -hydroxylamino group, a hydrazide group, an alkoxy group, a thioalkoxy group, an aminoxy group or an oximato group. An active amount of the compound of formula (I), the inhibitor, is administered into mammals as a pharmaceutically acceptable composition. The inhibitor is effective for a method for treating, for example, human cancers.
BARLOZZARI TERESA
HAUPT ANDREAS
ZIERKE THOMAS
KLING ANDREAS
| WO1997017364A1 | 1997-05-15 | |||
| WO1997022621A2 | 1997-06-26 | |||
| WO1996040751A1 | 1996-12-19 | |||
| WO1996040752A1 | 1996-12-19 | |||
| WO1993023424A1 | 1993-11-25 |