Title:
DOSAGE OF CATIONIC LIPOSOME CONTAINING ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JP2012229255
Kind Code:
A
Abstract:
To provide a dosage without a serious side effect of paclitaxel in a therapeutically effective amount used in a subject who has need thereof.
The cationic liposome formulation contains: about 30-99.9 mol% of at least one cationic lipid, at least about 0.1 mol% paclitaxel, and about 0-about 70 mol% of at least one neutral and/or anion lipid.
Inventors:
TEIFEL MICHAEL
MICHAELIS UWE
SAUER BIRGITTA
BARTELHEIM KERSTIN
BRUNNER CHRISTOPH
NAUJOKS KURT
MICHAELIS UWE
SAUER BIRGITTA
BARTELHEIM KERSTIN
BRUNNER CHRISTOPH
NAUJOKS KURT
Application Number:
JP2012159071A
Publication Date:
November 22, 2012
Filing Date:
July 17, 2012
Export Citation:
Assignee:
MEDIGENE AG
International Classes:
A61K31/337; A61K9/127; A61K31/335; A61K31/7068; A61K45/00; A61K47/18; A61K47/24; A61P9/00; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00
Domestic Patent References:
| JP2003514768A | 2003-04-22 |
Foreign References:
| WO1993018751A1 | 1993-09-30 | |||
| WO2002067928A2 | 2002-09-06 |
Other References:
JPN6012013090; ＡＵＤＯＵＹ，Ｓ．Ａ． ｅｔ ａｌ: 'Ｉｎ ｖｉｖｏ ｃｈａｒａｃｔｅｒｉｓｔｉｃｓ ｏｆ ｃａｔｉｏｎｉｃ ｌｉｐｏｓｏｍｅｓ ａｓ ｄｅｌｉｖｅｒｙ ｖｅｃｔｏｒｓ ｆｏｒ ｇｅｎｅ ｔｈｅｒａｐｙ' Ｐｈａｒｍ Ｒｅｓ Ｖｏｌ．１９， Ｎｏ．１１, 2002, ｐ．１５９９-６０５
JPN6012013091; ＨＯＲＴＯＢＡＧＹＩ，Ｇ．Ｎ． ｅｔ ａｌ: 'Ｃａｔｉｏｎｉｃ ｌｉｐｏｓｏｍｅ-ｍｅｄｉａｔｅｄ Ｅ１Ａ ｇｅｎｅ ｔｒａｎｓｆｅｒ ｔｏ ｈｕｍａｎ ｂｒｅａｓｔ ａｎｄ ｏｖａｒｉａｎ ｃａｎｃｅｒ ｃｅｌｌｓ ａｎｄ ｉｔｓ ｂｉｏｌｏｇ' Ｊ Ｃｌｉｎ Ｏｎｃｏｌ Ｖｏｌ．１９， Ｎｏ．１４, 2001, ｐ．３４２２-３３
JPN6012013094; ＯＥＴＴＬＥ，Ｈ． ｅｔ ａｌ: 'Ｐａｃｌｉｔａｘｅｌ ａｓ ｗｅｅｋｌｙ ｓｅｃｏｎｄ-ｌｉｎｅ ｔｈｅｒａｐｙ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ａｄｖａｎｃｅｄ ｐａｎｃｒｅａｔｉｃ ｃａｒｃｉｎｏｍａ' Ａｎｔｉｃａｎｃｅｒ Ｄｒｕｇｓ Ｖｏｌ．１１， Ｎｏ．８, 2000, ｐ．６３５-８
JPN6012013097; ＣＯＮＳＴＡＮＴＩＮＯＵ，Ｍ． ｅｔ ａｌ: 'Ｐａｃｌｉｔａｘｅｌ ａｎｄ ｃｏｎｃｕｒｒｅｎｔ ｒａｄｉａｔｉｏｎ ｉｎ ｕｐｐｅｒ ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ ｃａｎｃｅｒｓ' Ｃａｎｃｅｒ Ｉｎｖｅｓｔ Ｖｏｌ．２１， Ｎｏ．６, 200301, ｐ．８８７-９６
JPN6012013100; ＳＣＨＭＩＴＴ-ＳＯＤＹ，Ｍ． ｅｔ ａｌ: 'Ｎｅｏｖａｓｃｕｌａｒ ｔａｒｇｅｔｉｎｇ ｔｈｅｒａｐｙ： ｐａｃｌｉｔａｘｅｌ ｅｎｃａｐｓｕｌａｔｅｄ ｉｎ ｃａｔｉｏｎｉｃ ｌｉｐｏｓｏｍｅｓ ｉｍｐｒｏｖｅｓ ａｎｔｉｔｕｍｏｒａｌ ｅｆ' Ｃｌｉｎ Ｃａｎｃｅｒ Ｒｅｓ Ｖｏｌ．９， Ｎｏ．６, 200306, ｐ．２３３５-４１
JPN6012013091; ＨＯＲＴＯＢＡＧＹＩ，Ｇ．Ｎ． ｅｔ ａｌ: 'Ｃａｔｉｏｎｉｃ ｌｉｐｏｓｏｍｅ-ｍｅｄｉａｔｅｄ Ｅ１Ａ ｇｅｎｅ ｔｒａｎｓｆｅｒ ｔｏ ｈｕｍａｎ ｂｒｅａｓｔ ａｎｄ ｏｖａｒｉａｎ ｃａｎｃｅｒ ｃｅｌｌｓ ａｎｄ ｉｔｓ ｂｉｏｌｏｇ' Ｊ Ｃｌｉｎ Ｏｎｃｏｌ Ｖｏｌ．１９， Ｎｏ．１４, 2001, ｐ．３４２２-３３
JPN6012013094; ＯＥＴＴＬＥ，Ｈ． ｅｔ ａｌ: 'Ｐａｃｌｉｔａｘｅｌ ａｓ ｗｅｅｋｌｙ ｓｅｃｏｎｄ-ｌｉｎｅ ｔｈｅｒａｐｙ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ａｄｖａｎｃｅｄ ｐａｎｃｒｅａｔｉｃ ｃａｒｃｉｎｏｍａ' Ａｎｔｉｃａｎｃｅｒ Ｄｒｕｇｓ Ｖｏｌ．１１， Ｎｏ．８, 2000, ｐ．６３５-８
JPN6012013097; ＣＯＮＳＴＡＮＴＩＮＯＵ，Ｍ． ｅｔ ａｌ: 'Ｐａｃｌｉｔａｘｅｌ ａｎｄ ｃｏｎｃｕｒｒｅｎｔ ｒａｄｉａｔｉｏｎ ｉｎ ｕｐｐｅｒ ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ ｃａｎｃｅｒｓ' Ｃａｎｃｅｒ Ｉｎｖｅｓｔ Ｖｏｌ．２１， Ｎｏ．６, 200301, ｐ．８８７-９６
JPN6012013100; ＳＣＨＭＩＴＴ-ＳＯＤＹ，Ｍ． ｅｔ ａｌ: 'Ｎｅｏｖａｓｃｕｌａｒ ｔａｒｇｅｔｉｎｇ ｔｈｅｒａｐｙ： ｐａｃｌｉｔａｘｅｌ ｅｎｃａｐｓｕｌａｔｅｄ ｉｎ ｃａｔｉｏｎｉｃ ｌｉｐｏｓｏｍｅｓ ｉｍｐｒｏｖｅｓ ａｎｔｉｔｕｍｏｒａｌ ｅｆ' Ｃｌｉｎ Ｃａｎｃｅｒ Ｒｅｓ Ｖｏｌ．９， Ｎｏ．６, 200306, ｐ．２３３５-４１
Attorney, Agent or Firm:
Einzel Felix-Reinhard
Takuya Kuno
Takuya Kuno