DOUBLE-ACYLATED GLP-1 DERIVATIVE

Title:

DOUBLE-ACYLATED GLP-1 DERIVATIVE

Document Type and Number:

Japanese Patent JP2013144684

Kind Code:

A

Abstract:

To provide a derivative of a GLP-1 analogue suitable for oral administration and capable of being used, for example in treatment and/or prevention of all forms of diabetes and related diseases.

The invention relates to: a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37), a second K residue at a position corresponding to position 26 of GLP-1(7-37), and a maximum of ten amino acid modifications as compared to GLP-1(7-37), wherein the first K residue is designated K³⁷, and the second K residue is designated K²⁶. The derivative comprises two albumin binding moieties attached to K²⁶ and K³⁷, respectively; or a pharmaceutically acceptable salt, amide, or ester thereof.

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Inventors:

GARIBAY PATRICK WILLIAM
JANE SPETZLER
KODRA JANOS TIBOR
LINDEROTH LARS
LAU JESPER
SAUERBERG PER

Application Number:

JP2013030695A

Publication Date:

July 25, 2013

Filing Date:

February 20, 2013

Export Citation:

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Assignee:

NOVO NORDISK AS

International Classes:

C07K14/605; A61K38/26; A61K47/48; A61P1/00; A61P3/04; A61P3/10; A61P9/00; A61P15/00; A61P43/00

Domestic Patent References:

JP2002512175A	2002-04-23
JP2009536179A	2009-10-08
JP2008528658A	2008-07-31

Foreign References:

WO2009030738A1	2009-03-12
WO2009083549A1	2009-07-09
WO2008154619A1	2008-12-18

Attorney, Agent or Firm:

Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro

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