DPI FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN

Japanese Patent JP2015163634

A

PROBLEM TO BE SOLVED: To provide an inhalable dry powder formulation containing SAE-CD and an active agent.SOLUTION: The invention provides a dry powder formulation containing a dissociable powder carrier containing a powder active composition and SAE-CD. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.

WO/2002/102445	DRY POWDER INHALATION SYSTEM FOR TRANSPULMONARY ADMINISTRATION
JP2023067982	AMINOPHOSPHINIC DERIVATIVES FOR PREVENTING AND TREATING OCULAR INFLAMMATION
JP4401778	A method for producing a substance in which an active substance and a porous support are reacted with each other using a supercritical fluid.

PIPKIN JAMES D
ZIMMERER PUPERT O
HICKEY ANTHONY J
THOMPSON DIANE O
SMYTH HUGH D C

JP2015097967A

September 10, 2015

May 13, 2015

Click for automatic bibliography generation  

CYDEX PHARMACEUTICALS INC

A61K47/40; A61K9/00; A61K9/14; A61K31/352; A61P11/06; A61P37/08

JP2002524535A	2002-08-06
JP2003034652A	2003-02-07
JPH11171760A	1999-06-29
JP2003530425A	2003-10-14
JP2002503267A	2002-01-29

Junji Yuda
Noriyuki Takebayashi

Previous Patent: HAIR GROWTH AND/OR REGROWTH COMPOSITIONS

Next Patent: TREATMENT OF PORTAL HYPERTENSION AND RESTORATION OF HEPATIC FUNCTION WITH L-ORNITHINE PHENYLACETATE