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Title:
アルツハイマー病治療薬
Document Type and Number:
Japanese Patent JP5481739
Kind Code:
B2
Abstract:
To develop a highly safe measure to treat Alzheimer's disease using a secretase-inhibiting substance, there is provided a compound represented by the following general formula (I) or a salt thereof: wherein A represents a phenyl group or the like, R 1 represents a chlorine atom, a bromine atom, or a nitro group or the like, R 2 , R 3 , R 4 , and R 5 each represent a hydrogen atom or the like, and L represents CH 2 -CH 2 or CH=CH.

Inventors:
Hachiro Sugimoto
Takashi Takahashi
Ichiro Tsuchuro
Okuda Mitsuaki
Application Number:
JP2010514510A
Publication Date:
April 23, 2014
Filing Date:
May 27, 2009
Export Citation:
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Assignee:
National University Corporation Tokyo Institute of Technology
Kyoto University
International Classes:
C07C49/248; A61K31/12; A61K31/136; A61K31/138; A61K31/166; A61K31/192; A61K31/255; A61K31/404; A61K31/41; A61K31/4196; A61K31/44; A61K31/445; A61K31/4453; A61K31/495; A61K31/551; A61P25/28; A61P43/00; C07C49/255; C07C205/45; C07C217/18; C07C219/34; C07C225/22; C07C235/84; C07C311/29; C07D209/08; C07D211/32; C07D213/61; C07D241/04; C07D243/08; C07D249/08; C07D257/04; C07D295/06
Domestic Patent References:
JP5246779B22013-07-24
JP2008137914A2008-06-19
JP2008228686A2008-10-02
JP5246779B22013-07-24
Foreign References:
WO2003088927A22003-10-30
Other References:
JPN6009030165; OHTSU, Hironori et al.: 'Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids' Bioorganic & Medicinal Chemistry 11(23), 5083-5090, 2003
JPN6009030166; ISHIDA, Junko et al.: 'Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents' Bioorganic & Medicinal Chemistry 10(11), 3481-3487, 2002
JPN6009030167; JOHN, V. D. et al.: 'Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and th' Applied Organometallic Chemistry 20(8), 477-482, 2006
JPN6009030168; SHAO, Wei-Yan et al.: 'Facile preparation of new unsymmetrical curcumin derivatives by solid-phase synthesis strategy' Tetrahedron Letters 47(24), 4085-4089, 2006
JPN6013049588; Journal of Biochemistry and Molecular Biology Vol.38, No.4, 2005, p.474-80
JPN6013049590; Indian Journal of Chemistry Vol.34B, 1995, p.884-8
Attorney, Agent or Firm:
Kenichi Nomura
Setuko Mayama



 
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