PURPOSE: To provide a drug carrier having organ directiveness, esp. digestive organ directiveness, having its selective residence possibility inside the upper digestive organs carrying a drug thereon, consisting of a polymeric compound having both carboxyl group and cyclodextrin residue at the side chain.
CONSTITUTION: The carrier consisting of a polymeric compound pref. 1000-10000000 in the molecular weight of the main chain, having at the side chain 5-65wt.%, based on the polymeric compound, of carboxyl group and 1-90wt.%, based on the polymeric compound, of cyclodextrin residue (e.g. prepared by ester-linking of a cyclodextrin to an unsaturated carboxylic acid homopolymer or copolymer). This carrier can be obtained by activating the carboxylic acid segment of a polymer bearing carboxyl group at the side chain with a carbonyldiimidazole followed by reaction with a cyclodextrin.
KAYANO MASAKO
KASAMA TOSHIO
NOGUCHI YASUHISA
HONDA HIDEO
UCHIDA KATSUYUKI
GRELAN PHARMACEUTICAL CO
KOYAMA YOSHIYUKI