Title:
薬剤複合体組成物
Document Type and Number:
Japanese Patent JP4703566
Kind Code:
B2
Abstract:
The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human either of the compositions such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.
Inventors:
Unfrette, Godfrey
Jean, way
Fleming, Michael
Qi, Han-Way
Jean, way
Fleming, Michael
Qi, Han-Way
Application Number:
JP2006533133A
Publication Date:
June 15, 2011
Filing Date:
May 14, 2004
Export Citation:
Assignee:
Immunogen Incorporated
International Classes:
A61K39/395; A61K9/19; A61K31/537; A61K47/04; A61K47/12; A61K47/20; A61K47/26; A61K47/34; A61K47/48; A61P35/00
Domestic Patent References:
| JP2003503365A |
Foreign References:
| US20020001587 | ||||
| WO2001024763A1 |
Other References:
CHARI, R.V.J., et al.,Immunoconjugates Containing Novel Maytansinoids: Promising Anticancer Drugs,CANCER RESEARCH,1992年 1月 1日,Vol.52, No.1,p.127-131
LIU, C., et al.,Eradication of large colon tumor xenografts by targeted delivery of maytansinoids,Proceedings of the National Academy of Sciences of the United States of America,1996年 8月,Vol.93, No.16,p.8618-8623
LIU, C., et al.,Eradication of large colon tumor xenografts by targeted delivery of maytansinoids,Proceedings of the National Academy of Sciences of the United States of America,1996年 8月,Vol.93, No.16,p.8618-8623
Attorney, Agent or Firm:
Takashima Ichi