DRUG PREPARATION FOR TRANSCUTANEOUS ABSORPTION

Title:

DRUG PREPARATION FOR TRANSCUTANEOUS ABSORPTION

Document Type and Number:

Japanese Patent JPH03261721

Kind Code:

A

Abstract:

PURPOSE: To obtain a drug preparation for transcutaneous absorption having the stability as well as good transcutaneous absorbability of nicorandil by uniformly dispersing nicorandil in a base agent in the form of fine crystal particles having specific particle diameter and compounding a specific absorbefacient thereto.

CONSTITUTION: N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil) having antistenocardiac action is uniformly dispersed in a base agent in the form of fine crystal particles mostly having an average particle diameter of ≥2μm, preferably ≥4μm and the dispersion is compounded with 1-20wt.% (preferably 2-15wt.%) of an absorbefacient consisting of oleic acid and/or oleyl alcohol. A preferable transcutaneous absorbability can be imparted without lowering the stability of free nicorandil and an acrylic base agent can be used in the preparation.

Inventors:

IZUMOTO TANEYA
FUKUDA MUTSUMI
KAMINOYAMA TOMOHITO
SOGA WAKAKO

Application Number:

JP6068790A

Publication Date:

November 21, 1991

Filing Date:

March 12, 1990

Export Citation:

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Assignee:

SEKISUI CHEMICAL CO LTD
CHUGAI PHARMACEUTICAL CO LTD

International Classes:

A61K9/70; A61K9/06; A61K31/455; A61K47/10; A61K47/12; A61P9/08; A61P9/10; (IPC1-7): A61K9/70; A61K31/455; A61K47/10; A61K47/12

Attorney, Agent or Firm:

Kyozo Yuasa (4 outside)

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