Title:
ヒドロキシル化により活性化された薬剤遊離
Document Type and Number:
Japanese Patent JP4885356
Kind Code:
B2
Abstract:
The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly concerns anti-tumor prodrugs and those which are specifically activated by the hydroxylation activity of the P-450 enzyme CYP1B1. Also provided are methods of detection of aromatic oxidation activity.
Inventors:
Potter Gerrard Andrew
Patterson Lawrence Hilton
Burke Michael Danny
Patterson Lawrence Hilton
Burke Michael Danny
Application Number:
JP2000531195A
Publication Date:
February 29, 2012
Filing Date:
February 10, 1999
Export Citation:
Assignee:
Spare Serapeutex Limited
International Classes:
A61K47/48; A46B9/04; A61K31/27; A61K31/337; A61K31/37; A61K31/505; A61K31/513; A61K31/535; A61K31/536; A61K31/565; A61K31/70; A61K31/704; A61P35/00; A61P43/00; G07F17/30
Other References:
TEW K.D. et al.,Pharmac. Ther.,1989年,Vol.43,p.299-319
LOFTSSON T. et al.,International Journal of Pharmaceutics,1992年,Vol.79,p.107-112
MURRAY G.I. et al.,CANCER RESEARCH,1997年,Vol.57,p.3026-3031
LOFTSSON T. et al.,International Journal of Pharmaceutics,1992年,Vol.79,p.107-112
MURRAY G.I. et al.,CANCER RESEARCH,1997年,Vol.57,p.3026-3031
Attorney, Agent or Firm:
Hiroo Suzuki