Title:
【発明の名称】薬物ターゲティング
Document Type and Number:
Japanese Patent JP2001512425
Kind Code:
A
Abstract:
The invention provides a method of targeting a drug to areas of hypoxic and/or ischemic tissue within the body in which the desired drug species is linked to a non-cytotoxic bioreductive carrier. Also provided by the invention are novel bioreductive conjugates comprising a non-cytotoxic bioreductive moiety with linked-thereto at least one therapeutic agent. The compounds of the invention are particularly suitable for the treatment of rheumatoid arthritis and other arthritic conditions, diabetes, atherosclerosis, stroke, sepsis, Alzheimer's disease and other neurological disorders, cancer, kidney disease, digestive diseases, liver disease, chronic periodontitis or ischemia following tissue transplantation.
Inventors:
Break, david
Norton Declan
Adams, Jed
Stratford, Ian
Morris, Christopher
Jafar, mohamed
Nailer, matthew
Norton Declan
Adams, Jed
Stratford, Ian
Morris, Christopher
Jafar, mohamed
Nailer, matthew
Application Number:
JP53331898A
Publication Date:
August 21, 2001
Filing Date:
February 13, 1998
Export Citation:
Assignee:
Ceramark Limited
International Classes:
A61K31/573; A61K45/00; C07D209/08; C07D209/12; C07J5/00; A61K47/48; (IPC1-7): A61K47/48; A61K31/573; A61K45/00; C07D209/08; C07D209/12; C07J5/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)