Title:
癌の治療の薬剤及び方法
Document Type and Number:
Japanese Patent JP2005500259
Kind Code:
A
Abstract:
Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase and an inhibitor of cylcooxygenase-2 in a pharmaceutical composition. The agents and methods are used for chemoprevention and treatment of neoplasia including colorectal cancer and other cancers affecting epithelial cells throughout the body. The agents can also be used to treat the fibrosis that occurs with radiation therapy, as well as adenomatous polyps, including those with familial adenomatous polyposis (FAP).
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Inventors:
Manning, Pamela Tea
Connor, Jane Earle
Karen Sabert
Lao, Chinsara Parry V.
Lady, Bandar S
Connor, Jane Earle
Karen Sabert
Lao, Chinsara Parry V.
Lady, Bandar S
Application Number:
JP2002574911A
Publication Date:
January 06, 2005
Filing Date:
March 21, 2002
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
C07D335/06; A61K31/19; A61K31/198; A61K31/352; A61K31/382; A61K31/41; A61K31/415; A61K31/4375; A61K31/47; A61K31/55; A61K31/60; A61K31/66; A61K45/00; A61P35/00; A61P43/00; C07C257/14; C07C259/14; C07C317/50; C07C323/58; C07D215/54; C07D223/12; C07D257/04; C07D311/58; C07D311/92; C07D471/04; (IPC1-7): A61K31/198; A61K31/352; A61K31/382; A61K31/41; A61K31/4375; A61K31/47; A61K31/55; A61K45/00; A61P35/00; A61P43/00; C07C257/14; C07C259/14; C07C317/50; C07C323/58
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri