Title:
抗癌剤により誘発される末梢神経障害を予防および/または処置するための医薬品
Document Type and Number:
Japanese Patent JP2006508958
Kind Code:
A
Abstract:
A method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent of the family of platin compounds, taxanes, epothilone class, vinca alkaloids, said method comprising the administration in a co-ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies, an effective amount of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof. In case of prevention, acetyl L-carnitine is administered to a subject, in view of the need of a treatment with an anticancer agent, immediately before or immediately after surgical removal of the tumor, but in any case before the administration of the anticancer agent. Acetyl L-carnitine can enhance the supportive effect of physiological NGF during chemotherapy-induced neuropathy, thus avoiding the problem of the local and general side effects of the exogenous administration of NGF which are a major problem of this neuroprotective strategy.
Inventors:
Claudio Cavazza
Claudio Pisano
Loredana Vesi
Claudio Pisano
Loredana Vesi
Application Number:
JP2004551161A
Publication Date:
March 16, 2006
Filing Date:
October 23, 2003
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
A61K31/221; A61K31/205; A61P35/00; A61K31/28; A61K31/282; A61K31/335; A61K31/475; A61K31/555; A61K33/243; A61K38/14; A61K45/06; A61P25/02; A61P43/00
Domestic Patent References:
| JP2002521428A | 2002-07-16 |
Foreign References:
| US20010044465A1 | 2001-11-22 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Kazuaki Kojima
Michiko Matsutani
Mina Shiga
Kazuaki Kojima
Michiko Matsutani
Mina Shiga