Title:
統合失調症を処置するデュアルNK1/NK3アンタゴニスト
Document Type and Number:
Japanese Patent JP4490421
Kind Code:
B2
Abstract:
The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula wherein the substituents are as described herein or a pharmaceutically active acid-addition salt thereof. In particular, the invention provides methods for treating both positive and negative symptoms of schizophrenia through dual inhibition of NK1 and NK3 receptors. The invention also provides novel compounds with formula I and methods for preparing compounds of the invention.
Inventors:
Hoffmann, Torsten
Cobrett, andreas
Peters, Yens-Uwe
Schneider, Patrick
Slight, Andrew
Stadler, Heinz
Cobrett, andreas
Peters, Yens-Uwe
Schneider, Patrick
Slight, Andrew
Stadler, Heinz
Application Number:
JP2006518043A
Publication Date:
June 23, 2010
Filing Date:
June 25, 2004
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D213/75; A61K31/41; A61K31/44; A61K31/4418; A61K31/4427; A61K31/4439; A61K31/444; A61K31/4545; A61K31/46; A61K31/496; A61K31/4995; A61K31/5377; A61K31/5386; A61K31/54; A61K31/541; A61K31/547; A61K31/549; A61K31/551; A61K31/554; A61P25/00; C07D401/04; C07D401/14; C07D411/04; C07D413/04; C07D413/14; C07D417/04; C07D419/04; C07D451/02; C07D451/04; C07D451/06; C07D471/18; C07D487/00; C07D487/08; C07D491/10; C07D491/107; C07D495/10; C07D497/10; C07D498/08; C07D498/18; C07D513/08; C07D513/18; C07B53/00; C07B61/00
Domestic Patent References:
| JP2000247957A | ||||
| JP2001505881A | ||||
| JP2004536119A | ||||
| JP2004504301A | ||||
| JP2004504400A | ||||
| JP2004506718A | ||||
| JP8048669A |
Other References:
SARIA, A.,The tachykinin NK1 receptor in the brain: pharmacology and putative functions,European Journal of Pharmacology ,1999年,Volume 375, Issues 1-3,Pages 51-60
MINABE, Y. et al.,The effect of the acute and chronic administration of CP 96,345, a selective neurokinin1 receptor antagonist, on midbrain dopamine neurons in the rat: A single unit, extracellular recording study,Synapse,1996年,Volume 22 Issue 1,Pages 35 - 45
BURNET, P.W.J. et al.,Substance P (NK1) receptors in the cingulate cortex in unipolar and bipolar mood disorder and schizophrenia ,Biological Psychiatry,2000年,Volume 47, Issue 1,Pages 80-83
MINABE, Y. et al.,The effect of the acute and chronic administration of CP 96,345, a selective neurokinin1 receptor antagonist, on midbrain dopamine neurons in the rat: A single unit, extracellular recording study,Synapse,1996年,Volume 22 Issue 1,Pages 35 - 45
BURNET, P.W.J. et al.,Substance P (NK1) receptors in the cingulate cortex in unipolar and bipolar mood disorder and schizophrenia ,Biological Psychiatry,2000年,Volume 47, Issue 1,Pages 80-83
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda