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Title:
DYEING OF KERATINOUS FIBER
Document Type and Number:
Japanese Patent JPH11292830
Kind Code:
A
Abstract:

To provide a method for producing an aniline compound in high yield by condensing a dihalogenated hydrocarbon with an N-substituted aniline in a polar solvent in the presence of a basic compound, nitrosating the obtained compound, and reducing the nitrosated compound.

(A) A dihalogenated hydrocarbon of the formula X-CH2-Y-CH2-X {Y is (CH2)n [(n) is 0-8] or the like; X is a halogen} is condensed with (B) an N-substituted aniline of formula I (R is a 1-4C alkyl, a 2-4C hydroxyalkyl or the like; R1 is H, a halogen or the like) in a polar solvent (e.g. water) in the presence of a basic compound to provide (C) a compound of formula II, and the compound of formula II is nitrosated, preferably by the action of a mixture of sodium nitrite with hydrochloric acid in water at ≤10°C to provide (D) a compound of formula III. The compound of formula III is reduced to provide the objective aniline compound of formula IV [e.g. N,N'-bis (β- hydroxyethyl)-N,N'-bis(4'-aminophenyl)-1,3-diaminopropan-2-ol] in the method for producing the aniline compound.


Inventors:
JUNINO ALEX
GENET ALAIN
LANG GERARD
Application Number:
JP32792698A
Publication Date:
October 26, 1999
Filing Date:
November 18, 1998
Export Citation:
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Assignee:
OREAL
International Classes:
A61K8/33; A61K8/41; A61K8/49; A61Q5/10; B01J27/24; C07B61/00; C07C67/00; A61K8/00; C07C209/00; C07C209/10; C07C209/36; C07C209/76; C07C211/49; C07C211/51; C07C211/52; C07C211/53; C07C213/02; C07C215/14; C07C215/16; C07C215/18; C09B67/42; D06P3/08; (IPC1-7): C07C213/02; A61K7/13; C07C215/18; D06P3/08
Attorney, Agent or Firm:
Akira Asamura (1 person outside)