Title:
病的組織内への高分子輸送を評価するためのダイナミック造影ＭＲＩ法および薬剤
Document Type and Number:
Japanese Patent JP6896680
Kind Code:
B2
Abstract:
The present invention generally relates to paramagnetic contrast agents and a Dynamic Contrast Enhanced-MRI method for the non-invasive estimation of the delivery of a macromolecular anticancer drug or pro-drug within pathological tissues and, especially, in solid tumors and for the optimization of anticancer therapies.
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Inventors:
Raffaella Giavazzi
Alessandro Maiokki
Michele Moschetta
Giovanni Valbuza
Alessandro Maiokki
Michele Moschetta
Giovanni Valbuza
Application Number:
JP2018128238A
Publication Date:
June 30, 2021
Filing Date:
July 05, 2018
Export Citation:
Assignee:
BRACCO IMAGING S.P.A.
International Classes:
A61K49/10; A61B5/055
Domestic Patent References:
| JP2003531870A | ||||
| JP2015513551A |
Other References:
Boschi F, et al.,Tumor microvasculature observed using different contrast agents: a comparison between Gd-DTPA-Albumi,Magnetic Resonance Materials in Physics, Biology and Medicine,2008年,Vol.21, No.3,p.169-176
Preda A, et al.,MRI monitoring of Avastin antiangiogenesis therapy using B22956/1, a new blood pool contrast agent,,Journal of Magnetic Resonance Imaging,2004年,Vol.20, No.5,p.865-873
Galbraith SM et al.,Reproducibility of dynamic contrast-enhanced MRI in human muscle and tumours: comparison of quantitative and semi-quantitative analysis,NMR in Biomedicine,2002年,Vol.15, No.2,p.132-142
Preda A, et al.,MRI monitoring of Avastin antiangiogenesis therapy using B22956/1, a new blood pool contrast agent,,Journal of Magnetic Resonance Imaging,2004年,Vol.20, No.5,p.865-873
Galbraith SM et al.,Reproducibility of dynamic contrast-enhanced MRI in human muscle and tumours: comparison of quantitative and semi-quantitative analysis,NMR in Biomedicine,2002年,Vol.15, No.2,p.132-142
Attorney, Agent or Firm:
Norihito Yamao
Yasushi Ochiai
Yasushi Ochiai