Title:
動力学アッセイ
Document Type and Number:
Japanese Patent JP2004538447
Kind Code:
A
Abstract:
A hapten-linker-large group conjugate for use in a rapid assay, wherein the assay is kinetic-based not approaching equilibrium, the hapten-linker-large group conjugate being of the general formula: X-W-Y-Z wherein: X is a hapten; W is an optional thioether or ether group;Y is a linker of 10 or more atoms in length; and Z is a large group of sufficient size to provide steric hindrance with respect to the binding of X to a ligand in the absence of Y. Also provided are processes for the production of the conjugates, assay methods and kits. The assays of the invention utilising conjugates of the invention [(5)-OVA] provide a better sensitivity than the same assays with conjugates with shorter linkers [(2)-OVA and 3-OVA].
Inventors:
Cook, Christian John
Woo, incu
Michelle, John Stanton
Woo, incu
Michelle, John Stanton
Application Number:
JP2002589514A
Publication Date:
December 24, 2004
Filing Date:
May 14, 2002
Export Citation:
Assignee:
THE HORTICULTURE AND FOOD RESEARCH INSTITUTE OF NEW ZEALAND LIMITED
International Classes:
C07J33/00; C07J43/00; C07K14/76; G01N33/53; G01N33/531; G01N33/543; (IPC1-7): G01N33/53; C07K14/76; G01N33/531
Attorney, Agent or Firm:
Akio Miyazaki
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki