Title:
ＥＲＢＢ－２、ＥＲＢＢ－２／ＥＲＢＢ－３陽性腫瘍を有する個体の処置のための、ＥＲＢ－２及びＥＲＢＢ－３の細胞外部分上のエピトープに結合する抗原結合部位を含むＥＲＢＢ－２標的化剤及び二重特異性抗体
Document Type and Number:
Japanese Patent JP7304815
Kind Code:
B2
Abstract:
The invention relates among others to antibodies comprising a first antigen- binding site that binds ErbB-2 and a second antigen-binding site that binds ErbB- 3. The antibodies can typically reduce a ligand-induced receptor function of ErbB-3 on a ErbB-2 and ErbB-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an ErbB-2, ErbB-3 or ErbB-2/3 positive tumor.
Inventors:
Marc Slossby
Cecilia Anna Wilhelmina Gewien
David Andre Baptiste Mossang-Deu-Taille
Ton Rugtenberg
Cecilia Anna Wilhelmina Gewien
David Andre Baptiste Mossang-Deu-Taille
Ton Rugtenberg
Application Number:
JP2019553429A
Publication Date:
July 07, 2023
Filing Date:
April 03, 2018
Export Citation:
Assignee:
Mels Namrose Fennote Shap
International Classes:
A61K39/395; A61K31/282; A61K31/337; A61K31/357; A61K31/475; A61K31/7068; A61K47/68; A61P35/00; A61P43/00
Domestic Patent References:
| JP2017507944A |
Other References:
Mol Cancer Ther, 2012, Vol. 11, No.3, pp.582-593
Journal of Clinical Oncology, 2014, Vol. 32, Issue 15, Meeting abstract No. 651
MABS, 2016, Vol. 8, No. 7, pp. 1195-1209
Journal of Clinical Oncology,2017年06月20日,Vol. 35, No. 15, Supp. Supplement 1,Abstract No. 2522
Journal of Clinical Oncology, 2014, Vol. 32, Issue 15, Meeting abstract No. 651
MABS, 2016, Vol. 8, No. 7, pp. 1195-1209
Journal of Clinical Oncology,2017年06月20日,Vol. 35, No. 15, Supp. Supplement 1,Abstract No. 2522
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mihiro
Tatsuhiko Abe
Shinya Mihiro
Tatsuhiko Abe