To provide a medicine for inhibiting the release of elastase associated with ischemia reperfusion disorder observed in cerebral infarction, heart diseases, renal diseases, etc., and also inflammatory diseases such as chronic bronchitis, asthma, etc.
This elastase release inhibitor is a hydroxyaliphatic sulfonic acid analog expressed by the formula [wherein, X is ethylene, vinylene or ethynylene group; Y is ethylene, vinylene, ethynylene, OCH2 or S(O)pCH2; (p) is 0, 1 or 2; (m) is 1 to 5 integer; (n) is 0 to 4 integer; R1 is a 1-8C alkyl or the like; R2 is H or methyl and the R1, R2 bond each other to form a 3-8C cycloalkyl; R3 is H or a 2-8C acyl; R4 is OR5 or NHR6; R5 is H, a 1-4C alkyl, an alkali metal, an alkaline earth metal or ammonium; and R6 is H or a 1-4C alkyl].
| JP2002513407 | [Title of Invention] N-Hydroxy4-sulfonylbutaneamide compound |
| JP2006188525 | CELL PROLIFERATION INHIBITOR |
MIYATA NORIYUKI
ONO NAOYA
NAGANAMI TOMOMICHI
HIRANO HITOMI
TODA YOSHIHISA
TANAMI TOORU
OKUYAMA SHIGERU
UNIV TEXAS
Tomizo Kitagawa