Title:
過酸化物レベルを減少させるエラストマー処理方法
Document Type and Number:
Japanese Patent JP4214215
Kind Code:
B2
Abstract:
A novel process has been developed for the treatment of crosslinked ethylene-propylene diene monomer (EPDM) elastomer material to decrease its residual peroxide levels. EPDM is used to form the seats and neck gaskets of metering valves used in metered-dose inhalers (MDI). For filled and inverted MDI units these EPDM components are in direct contact with the pharmaceutical formulation media. The process involves exposing the EPDM valve components to a solution of 2-mercaptoethanol, a chemical reducing agent. The 2-mercaptoethanol greatly diminishes the residual peroxide levels in EPDM by reducing the peroxide functional groups to the corresponding hydroxyl groups. EPDM components treated in this manner have demonstrated very low peroxide levels and, consequently, greatly improved compatibility with the pharmaceutical formulation in the inhaler. An advantage of this approach is that the treated EPDM would likely retain its favorable physical properties and its good performance in metering valves. In this work 2-mercaptoethanol was used as the model reducing agent. It is believed, however, that similar positive results can be obtained using other reducing agents, notably other volatile compounds containing sulfur in one of its lower valence states (i.e. other thiol compounds or sulfur dioxide).
Inventors:
Girotta Carl M
Disilva Joseph
Disilva Joseph
Application Number:
JP53321398A
Publication Date:
January 28, 2009
Filing Date:
February 04, 1998
Export Citation:
Assignee:
Aventis Pharmaceuticals, Inc.
International Classes:
A61K9/72; A61K31/58; C08L23/16; A61M15/00; C08F6/00; C08F6/28; C08F8/00; C08J7/12; C09K3/10
Domestic Patent References:
| JP49020073B1 | ||||
| JP8333420A |
Foreign References:
| US3468855 | ||||
| US3925333 |
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Kenji Asai
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Kenji Asai