To provide a new osmium-based electrochemical species for detecting a wide variety of analytes using immunological techniques using an electrochemical oxidation/reduction label (also called an electron transfer agent or an electrochemical mediator label).
The new osmium-based electrochemical species usable in an immunoassay is provided. The osmium species can bond with a specific binding ligand for detecting related analytes and further can contain 1, 2 or 4 osmium centers that bond with the specific binding ligand using various bonding groups. Test sensors and diagnostic kits supporting electrode structures that can be used with the osmium-based electrochemical species are also provided. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal desired to analyze analytes that may be present at low concentration.
GHOSHAL MITALI
DENG DAVID Z
TSAI JANE SHIOW-CHUAN
Ishii Teiji
Satoshi Fujita
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