Title:
流体種の電子的制御
Document Type and Number:
Japanese Patent JP4630870
Kind Code:
B2
Abstract:
Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.
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Inventors:
Link, Darren Earl.
Weights, Divit A.
Cristobal-Ascarte, Gradel
Chen, Cheng Dong
Anne, Kweng Ho
Weights, Divit A.
Cristobal-Ascarte, Gradel
Chen, Cheng Dong
Anne, Kweng Ho
Application Number:
JP2006524885A
Publication Date:
February 09, 2011
Filing Date:
August 27, 2004
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
B01J19/00; B01D17/06; B01F5/06; B01F13/00; B01J19/08; B81B1/00; G01N15/14; B01F5/02
Domestic Patent References:
| JP2002528699A | ||||
| JP2002536167A | ||||
| JP2005515878A | ||||
| JP2006500596A | ||||
| JP2006523142A |
Attorney, Agent or Firm:
Takeshi Oshio