Title:
ELECTROPHILIC FLUORINATING METHOD
Document Type and Number:
Japanese Patent JPS5223063
Kind Code:
A
Abstract:
The Specification describes a synthetic route for the preparation of a 9,11-dehydro-3-oxygenated 17 alpha -hydroxy-20-ketopregnane which comprises the steps (i) electrophilically fluorinating a saturated 9,11-unsubstituted 3-oxygenated-17 alpha -(esterified hydroxy)-20-ketopregnane, (ii) dehydrofluorinating the resulting 9 alpha -fluorosteroid, if desired after transformations elsewhere in the molecule have been effected, and (iii) cleaving the ester group at the 17 alpha -position to generate a 17 alpha -hydroxy group.
Inventors:
DEIRETSUKU HARORUDO RICHIYAADO
ROBAATO HENRII HETSUSE
ROBAATO HENRII HETSUSE
Application Number:
JP5898276A
Publication Date:
February 21, 1977
Filing Date:
May 21, 1976
Export Citation:
Assignee:
RES INST MEDICINE CHEM
International Classes:
C07J5/00; C07J41/00; C07J7/00; (IPC1-7): C07B9/00; C07J5/00; C07J7/00