エモジンスクシニルエステル系化合物およびその調製方法と用途

Japanese Patent JP7210605

B2

Disclosed in the present invention are an emodin succinyl ester compound, a preparation method therefor and a use thereof, the emodin succinyl ester compound having the structure as represented by formula I (R being a C_1-5alkyl group). The method provided in the present invention has a simple method course, and may effectively save time in synthesis and reduce costs, being simple to operate, being easy to implement, and being suitable for industrial production. Experiments show that the emodin succinyl ester compound of the present invention may better promote the healing of diabetic wounds than emodin, and may be used for preparing a drug for promoting the healing of diabetic wounds. Moreover, it has been confirmed by means of performing pharmacological experiments on rats suffering from experimentally mixed hyperlipidemia that the emodin succinyl ester compound of the present invention is superior to emodin, and has the advantages of having a remarkable blood fat lowering effect, being safe, being simple and convenient to administer, the raw materials being low cost and readily available, and being easy to transport and store.

Yang Baofeng
Xiao Wei
Zhang Yong
Chimin Du
King Jinhui
Wang Zhong
White Unryu
Lu Yanjie
Gakuseki Huang
Huh super thousand
Lee Kin

JP2020549851A

January 23, 2023

November 30, 2018

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Jiangsu Kouen Pharmaceutical Co., Ltd.

C07C69/40; A61K9/06; A61K9/08; A61K9/12; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K9/70; A61K31/235; A61K47/44; A61P1/16; A61P3/06; A61P3/10; A61P17/02; C07C67/08; C07C67/14; C07C67/56

JP2002520260A

CN105663099A

Tingfang Chen,Emodin Ameliorates High Glucose Induced-Podocyte Epithelial-Mesenchymal Transition In-Vitro and In-Vivo,Cellular Physiology and Biochemistry,2015年,P.1425-1436

Masataka Kotani
Aya Usami

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