Title:
医療目的の為のペルフルオロ有機化合物の乳濁液、前記乳濁液を生産する為の方法並びに当該乳濁液の助けにより疾患を治療及び予防する為の方法
Document Type and Number:
Japanese Patent JP2004504344
Kind Code:
A
Abstract:
An emulsion of perfluoroorganic compounds (PFOCs) with gas-transporting properties for intravascular administration comprises a perfluorocarbon rapidly eliminable from the organism and a perfluorinated tertiary amine slowly eliminable from the organism and further comprises at least three kinds of PFOC admixtures taken in small amounts, which are close in their structure and physicochemical properties to the main components and make up a series of PFOCs with gradually changing properties. The emulsion also contains minor admixtures of H-perfluoroalkanes. Such a composition contributes to the formation of a more homogeneous and stable non-clustered perfluorocarbon phase inside the emulsion particles. The PFOC emulsion is stabilized by a polyoxyethylene-polyoxypropylene copolymer. The formulation of the composition provides stability of the emulsion under storage and on entry into the blood flow, as well as a low viscosity of the PFOC emulsion, which secures a high dynamic oxygen capacity of the preparation and improves the delivery of oxygen to tissues. When preparing the emulsion, the stabilizing agent is heated at a temperature of up to 75 DEG C, all the components are saturated with carbon dioxide gas, and the homogenization is carried out with feeding carbon dioxide gas, whereby the origination of peroxides is minimized and the reactogenicity is thus reduced. It is proposed to use PFOC emulsions as a means for treating air-and fat embolism, obliterating vascular injuries of extremities and poisoning with lipophilic poisons, as well as for preventing toxic injuries caused by various xenobiotics.
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Inventors:
Maevsky, Evgeny Ileach
Ivanitsky, Genlihiro Romanovich
Makarov, Kirill Nikolaevich
Krakova, Galena Mikhailovna
Archipov, Vladimir Victorovich
Moroz, Victor Basilievich
Staroboitova, Lyudmila Nikolaevna
Senina, Lysa Yakovlevna
Pushkin, Sergey Yuryevich
Ibashina, Albina Ivanofuna
Ivanitsky, Genlihiro Romanovich
Makarov, Kirill Nikolaevich
Krakova, Galena Mikhailovna
Archipov, Vladimir Victorovich
Moroz, Victor Basilievich
Staroboitova, Lyudmila Nikolaevna
Senina, Lysa Yakovlevna
Pushkin, Sergey Yuryevich
Ibashina, Albina Ivanofuna
Application Number:
JP2002513453A
Publication Date:
February 12, 2004
Filing Date:
July 20, 2000
Export Citation:
Assignee:
Otokritoe Aktionernoe Obscest Bonautino-Proise Bodst Bennaya Filma "Perfutran"
International Classes:
C07D295/06; A61K9/00; A61K9/10; A61K9/107; A61K31/02; A61K31/025; A61K31/13; A61K31/402; A61K31/445; A61K33/00; A61K33/06; A61K33/14; A61K33/42; A61K45/06; A61K47/04; A61K47/26; A61K47/34; A61P7/00; A61P7/08; A61P9/08; A61P9/10; C09K23/42; (IPC1-7): A61K31/025; A61K9/10; A61K31/13; A61K31/402; A61K31/445; A61K47/04; A61K47/26; A61K47/34; A61P7/00; A61P9/08
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji