Title:
ENANTIOMERICALLY PURE β-D-DIOXOLANE-NUCLEOSIDE
Document Type and Number:
Japanese Patent JP2004149543
Kind Code:
A
Abstract:
To provide a enantiomerically pure dioxolane nucleoside having excellent anti-HIV activity.
The method and a composition for therapeutic treatment of an infected human with HIV (human immunodeficiency virus) include administration of an HIV therapeutic amount of enantiomerically pure β-D-dioxanylpurine nucleoside, having formula (I) in an pharmaceutically permissible optional carrier or diluent. (Wherein R is OH, Cl, NH2, H or a pharmaceutically permissible salt or derivative of the compound.).
Inventors:
CHU CHUNG K
SCHINAZI RAYMOND F
SCHINAZI RAYMOND F
Application Number:
JP2003414876A
Publication Date:
May 27, 2004
Filing Date:
December 12, 2003
Export Citation:
Assignee:
UNIV OF GEORGIA RES FOUNDATION
UNIV EMORY
UNIV EMORY
International Classes:
A61K31/505; A61K31/506; A61K31/513; A61K31/52; A61K31/522; C07D473/18; A61K31/53; A61K31/675; A61K31/7076; A61K38/21; A61P31/12; A61P31/18; A61P37/04; C07D327/04; C07D405/04; C07D411/04; C07D473/00; C07D473/16; C07D473/30; C07D473/34; C07D473/40; C07D497/08; C07F9/6561; (IPC1-7): C07D473/16; A61K31/52; A61P31/18
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Akio Ichiiri
Makoto Ono
Katsuma Osaki
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